NOVEL ISOXAZOLE DERIVATIVE AND SALT THEREOF

摘要

An isoxazole derivative represented by general formula (1), a salt thereof, a process for the production thereof, an inhibitor for lipoxygenase and cyclooxygenase containing an effective dose of the derivative and a pharmaceutical carrier, and a method of inhibiting lipoxygenase and cyclooxygenase by administering the derivative to a patient. In formula (1) R and R<1> may be the same or different from each other and each represents hydrogen, lower alkyl, lower alkoxy or halogen; m represents 0 to 5; A represents -NH-, -O- or a direct bond; B represents -C(=Z)-NH-, -C(=Z)-(CH=CH)l- or -CH=CH-, wherein Z represents oxygen or sulfur, and l represents 0 to 2; X represents nitrogen or carbon; n represents 0 to 3; and Y represents hydroxy, lower alkoxy, lower alkoxycarbonyloxy, etc.; provided that m represents 1 to 5 when A represents -NH-.