摘要 |
<p>The present invention provides a novel kit for detecting a genetic predisposition for vascular aneurysms in a mammal suspected of having a genetic predisposition for vascular aneurysms. The kit comprises primers capable of amplifying at least a portion of the Type III procollagen genomic DNA, or at least a portion of the cDNA synthesized from the mRNA transcribed from the Type III procollagen gene, in a tissue or fluid sample from the mammal; and a standard nucleic acid sequence for Type III procollagen for determining at least one difference in nucleotide base sequence of corresponding regions of the sample DNA, whereby a difference in the base sequence of the DNA from the sample as compared with the standard sequence indicates an increased likelihood of said mammal suffering from a vascular aneurysm.</p> |