摘要 |
<p>A process for producing α-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of formula (II), wherein R?1, R2 and R3¿ can be hydrogen, alkyl, alkoxy, halo, phenyl, substituted phenyl, or hydroxy; A can be S, O or -CH¿2?-; and Alk is straight or branched chain alkylene, with a base in an aprotic solvent, then reacting the resulting alkoxide with a monohaloacetic acid ester to give an alkoxyacetate followed by reaction of the alkoxyacetate with a hydrogen halide, organic acid or Lewis acid in nitromethane to give the corresponding α-alkoxyacetic acid which then may be recovered or may optionally be converted to the corresponding salt by contacting the α-alkoxy acetic acid with a base.</p> |