SUBSTITUTED DIHYDROXY-BIS-[5-HYDROXY-2(5H)-FURANONE-4-YL]-ALKANES AS ANTI-INFLAMMATORY AGENTS

摘要

Compounds of formula (I) in which R1 is H or alkyl of 1 to 20 carbons, CO-R2, CO-O-R2, CO-NH-R2, or PO(OR2)2 or PO(OR2)R2, where R2 independently is H, alkyl of 1 to 20 carbons, phenyl, or lower alkyl substituted phenyl or halogen substituted phenyl; n is an integer between 8 to 14; Y is H, alkyl having 1 - 20 carbon atoms, aryl[lower alkyl], aryl, lower alkyl[aryl], alkenyl containing one or more olephinic bonds and 1-20 carbon atoms, CO-R3, CO-OR3, CONHR3, SO2R3, SO2NHR3 where R3 is aryl[lower alkyl], aryl, lower alkyl[aryl], alkenyl containing one or more olephinic bonds and 1-20 carbon atoms, further Y is PO(OH)2, PO(OH)OR4, PO(OH)R4 or PO(OR4)2, where R4 is independently alkyl of 1 - 20 carbons or phenyl, have anti-inflammatory activity.