TRANSMISSION-BLOCKING VACCINE AGAINST MALARIA

摘要

The present invention relates to transmission-blocking vaccines against malaria, vaccines of the present invention containing a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells, and to yeast cells producing the protein. Mice and monkeys inoculated with the yeast-expressed Pfs25 of the present invention have developed antibodies with transmission-blocking activity. The present invention also relates to methods of preventing or treating malarial infections using the vaccines of the present invention.