摘要 |
The invention provides new N-imidazolyl derivatives of substituted tetrahydrocarbazoles and cyclopent[b]indoles of general formula (I) <CHEM> wherein n is 1 or 2; p is an integer of 1 to 4; A is a straight or branched C1-C4 alkylene chain; B is a direct linkage, a straight or branched, unsaturated or saturated C1-C4 alkylene chain; Q is a direct linkage or a straight or branched C1-C4 alkylene chain; each of R1 and R2 independently is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulfonyl, halogen or trihalomethyl; each of R3 and R5, independently is hydrogen or C1-C4 alkyl; R4 is -OR6 or -N(R6,R7) group, wherein each of R6 and R7 independently is hydrogen, C1-C4 alkyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of a disease state in which an enhancement of TxA2 synthesis exerts a pathogenic effect. |