| 摘要 |
RAN 4430/047 Compounds of the formula I wherein R1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, heterocyclylcarbonyl or a group of the formula (i); R2 represents alkyl, cycloalkylalkyl or aralkyl; R3 represents hydrogen and R4 represents hydroxy or R3 and R4 together represent oxo; R5 represents alkoxycarbonyl or alkylcarbamoyl; R6 and R7 together represent trimethylene or tetramethylene optionally substituted by alkyl or on adjacent carbon atoms by tetramethylene; R8 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aroyl, aralkanoyl or heterocyclylcarbonyl; and R9 represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, cyanoalkyl, carbamoylalkyl, alkylthioalkyl, alkoxyalkyl or alkoxycarbonylalkyl, and pharmaceutically acceptable acid addition salts of those compounds of formula I which are basic, inhibit aspartyl proteases of viral origin and can be used in the form of medicaments for the prophylaxis or treatment of viral infections. They can be manufactured according to generally known methods.
|
