<p>Microcapsules are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microcapsules and (ii) reducing the water-solubility of at least the outside of the intermediate microcapsules. Suitable wall-forming materials include proteins such as albumin and gelatin. The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.</p>
申请公布号
EP0512693(A1)
申请公布日期
1992.11.11
申请号
EP19920303236
申请日期
1992.04.10
申请人
DELTA BIOTECHNOLOGY LIMITED
发明人
SUTTON, ANDREW DEREK, DELTA BIOTECHNOLOGY LTD.;JOHNSON, RICHARD ALAN, DELTA BIOTECHNOLOGY LTD.;SENIOR, PETER JAMES, DELTA BIOTECHNOLOGY LTD.;HEATH, DAVID, DELTA BIOTECHNOLOGY LTD.