| 摘要 |
<p>Piperazine derivatives of formula I <CHEM> and their pharmaceutically acceptable acid addition salts are 5-HTlA binding agents, particularly 5-HTlA antagonists and may be used, for example, as anxiolytics. In the formula A is C2-4 alkylene chain optionally substituted by lower alkyl, Z is oxygen or sulphur, R is hydrogen or lower alkyl, R<1> is a mono or bicyclic aryl or heteroaryl radical, R<2> is a mono or bicyclic heteroaryl radical and R<3> is hydrogen or a specified radical such as lower alkyl, cycloalkyl, aryl, heteroaryl or optionally substituted amino.</p> |
