SULFONAMIDOLPHENYL DERIVATES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRYTHMIA CONTAINING SAME

摘要

Piperidine compounds of general formula (XX) are provided which are useful as medicaments for the treatment or prophylaxis of arrhythmia. in which R<1> is a lower alkyl and W is: wherein X is -S-, -SO- or -SO2-; R<2> is hydrogen or -(CH2)n-Y; n is an integer of 1 to 5; Y is an aryl, pyridyl or a substituted pyridyl group; X min is -CO- or -CH(OH)-; p is an integer of 1 to 4; R<1><2> is hydrogen or a lower alkyl group; Y min is -(CH2)m-A; m is 1 or 2; A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl group; R<1><2> and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents; and R<2><2> is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.