| 摘要 |
The present invention relates to aromatic derivatives of formula:
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in which:
- Ar' represents an unsubstituted phenyl or a phenyl substituted one or more times by a halogen atom, preferably a chlorine or fluorine atom, by a C1-C3 alkyl, by a trifluoromethyl, by a C1-C3 alkoxy, by a hydroxyl; or a thienyl, pyridyl or naphthyl group, the said groups being unsubstituted or substituted by a halogen, preferably a chlorine or fluorine atom, an indolyl group or a benzothienyl group;
- R represents hydrogen, a methyl group or a (CH2)n-L group, where n is an integer from 2 to 6 and L is hydrogen or an amino group;
- Z and Z' independently represent a hydrogen atom or a group M or OM, M represents hydrogen, a straight or branched C1-C6 alkyl; an alpha -hydroxybenzyl, an alpha -alkylbenzyl or a phenylalkyl in which the alkyl group comprises 1 to 3 carbon atoms, unsubstituted or mono- or polysubstituted on the aromatic ring by a halogen, a hydroxyl, an alkoxy containing 1 to 4 carbon atoms or an alkyl containing 1 to 4 carbon atoms; a pyridylalkyl in which the alkyl group comprises 1 to 3 carbon atoms; a naphthylalkyl in which the alkyl group comprises 1 to 3 carbon atoms; a pyridylthioalkyl in which the alkyl group comprises 1 to 3 carbon atoms; a styryl; a (1-methyl)-2-imidazolylthioalkyl in which the alkyl group comprises 1 to 3 carbon atoms; a 1-oxo-3-phenylindan-2-yl; an aromatic or heteroaromatic group, the said group being unsubstituted or substituted;
- T' represents a bond, a -CH2- group or a -C(O)- group;
- T represents a group chosen from
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W being an oxygen or sulphur atom, provided that
. when Z' is hydrogen or OM, T' is other than a bond; and
. when Z is hydrogen or OM, T is other than a -C(W)-NH group;
or one of their possible salts with inorganic or organic acids, or their quaternary ammonium salts.
<??>APPLICATION: treatment of any substance P- and neurokinin-related pathology, especially analgesia and inflammation.
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