| 摘要 |
A compound of the structure <IMAGE> wherein R1 is <IMAGE> R3 is hydrogen, alkyl, arylalkyl, (CH2)sNR4R5, aminoalkyl, hydroxyalkyl, guanylalkyl, mercaptoalkyl, alkylthioalkyl, indolylmethyl, hydroxyphenylmethyl, imidazolylmethyl or phenyl which is optionally mono-, di-, or tri-substituted; R4 is hydrogen, alkyl, or aralkyl; R2 and R5 are each independently hydrogen, formyl, alkanoyl, arylalkanoyl, aryloyl, or CO2R6; R6 is alkyl, arylalkyl, allyl, fluorenylmethyl, or phenyl which is optionally mono-, di-, or tri-substituted; m is 0-4; n is 0-4; p is 0-1; q is 0-4; r is 0-4; and s is 0-4; or a pharmaceutically acceptable salt thereof, which by virtue of its immunosuppressive activity is useful in treating transplantation rejection, host vs. graft disease, autoimmune diseases, and diseases of inflammation, by virtue of its antifungal activity is useful in treating fungal infections; and by virtue of its antitumor activity is useful in treating tumors.
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