| 摘要 |
A method for dehalogenating a compound of the generalized structure <IMAGE> I is disclosed where: R1, R2 and R3 independently are hydrogen or methyl or R1 and R3 taken together represent methylene, with the proviso that R1, R2 and R3 are not all methyl; X is a halogen; m is zero, 1 or 2; and Y is a pharmaceutically acceptable acid. The method comprises contacting compound I with a catalytic hydrogenolysis system to replace the halogen with a hydrogen. A particularly preferred hydrogenolysis system comprises Pd/C and ammonium formate. A preferred starting material is <IMAGE>
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