发明名称 |
Amine derivatives of anthracycline antibodies |
摘要 |
Novel antineoplastic amine-containing derivatives and methods for synthesizing such derivatives of anthracycline antibiotics are disclosed. The derivatives are useful to anthracycline antibiotic conjugates which retain substantial immunospecificity of the unconjugated antibody molecule. Using the conjugates, targeted delivery of the attached antibiotics is achieved in vivo. Such conjugates are thus therapeutically effective against a variety of neoplastic cellular disorders when administered in vivo. Methods for preparing the antibody conjugates and for use of the conjugates in vivo are also disclosed.
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申请公布号 |
US5162512(A) |
申请公布日期 |
1992.11.10 |
申请号 |
US19880199549 |
申请日期 |
1988.05.27 |
申请人 |
CYTOGEN CORPORATION |
发明人 |
KING, H. DALTON;LOPES, ANTHONY D.;RADCLIFFE, ROBERT D.;RODWELL, JOHN D.;COUGHLIN, DANIEL J. |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K39/395;A61K41/00;A61K47/48;A61K51/10;A61P31/04;C07H15/252;C07K5/083;G01N33/531;G01N33/543 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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