RAPID INDUCIBLE BETA-LACTAMASE SCREEN TEST

摘要

2086507 9219763 PCTABS00017 In an assay for determination of beta-lactam antibiotic resistance in a target bacterial strain, the strain is grown in the presence of both a beta-lactamase inducing antibiotic and a beta-lactam indicator antibiotic which kills or inhibits the growth of bacteria unable to hydrolyze beta-lactam antibiotics. Growth, indicative of drug resistance in the target strain, is monitored by detecting a fluorophor released by the enzymatic cleavage of a metabolizable fluorogenic compound.