发明名称 |
Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
摘要 |
A pharmaceutical composition which comprises particles of a finely divided pharmaceutically acceptable water soluble diluent coated with microcrystalline particles of nifedipine, the majority of which have a particle size of 100 micrometres or less in the presence of polyvinylpyrrolidone, the polyvinylpyrrolidone being present in an amount of from 10 to 90% by weight based on the weight of the nifedipine. The incorporation of polyvinylpyrrolidone in an amount of less than the amount of nifedipine significantly slows the dissolution of nifedipine from the finished solid dosage form. |
申请公布号 |
PH26850(A) |
申请公布日期 |
1992.11.05 |
申请号 |
PH19390000400 |
申请日期 |
1990.02.09 |
申请人 |
ETHICAL PHARMACEUTICALS LTD. |
发明人 |
ALAN RHODES |
分类号 |
A61K9/58;A61K9/14;A61K9/16;A61K9/18;A61K9/20;A61K9/52;A61K31/44;A61K31/455;A61P9/12 |
主分类号 |
A61K9/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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