| 摘要 |
IN THE CANADIAN PATENT AND TRADEMARK OFFICE PATENT APPLICATION entitled: New dialkylenepiperidino compounds and their enantiomers, process for preparing them and pharmaceutical compositions containing them. in the name of: Xavier EMONDS-ALT Isabelle GROSSRIETHER Vincenzo PROIETTO Didier VAN BROECK Assignee: ELF SANOFI The invention relates to aromatic amino derivatives of formula: (I) in which: - Ar' represents a phenyl, unsubstituted or substituted one or more times with a halogen atom, preferably a chlorine or fluorine atom, with a C1-C3 alkyl, with a trifluoromethyl, with a C1-C3 alkoxy, with a hydroxyl; a thienyl, pyridyl or naphthyl group, the said groups being unsubstituted or substituted with a halogen, preferably a chlorine or fluorine atom, an indolyl group or a benzothienyl group; - R represents hydrogen, a methyl group or a group (CH2-)n-L, where n is an integer from 2 to 6 and L is hydrogen or an amino group; Z and Z' represents, independently, a hydrogen atom or a group M or OM, - M represents hydrogen or a linear or branched C1-C6 alkyl; an .alpha.-hydroxybenzyl, an .alpha.-alkylbenzyl or a phenylalkyl in which the alkyl group contains 1 to 3 carbon atoms, unsubstituted, mono- or polysubstituted on the aromatic ring with a halogen, a hydroxyl, an alkoxy of 1 to 4 carbon atoms, an alkyl of 1 to 4 carbon atoms; a pyridylalkyl in which the alkyl group contains 1 to 3 carbon atoms; a naphthylalkyl in which the alkyl group contains 1 to 3 carbon atoms; a pyridylthioalkyl in which the alkyl group contains 1 to 3 carbon atoms; a styryl; a l-methyl-2-imidazolylthioalkyl in which the alkyl group contains 1 to 3 carbon atoms; a l-oxophenyl-3-indan-2-yl; an aromatic or heteroaromatic group, the said group being unsubstituted or substituted, - T' represents a bond, a -CH2- group or a -C(O)- group; - T represents a group selected from and W being an oxygen or sulphur atom, with the limita tion that ? when Z' is hydrogen or OM, T' is other than a bond; and ? when Z is hydrogen or OM, T is other than a group -C(W)-NH-, or one of their possible salts with inorganic or organic acids, or one of their quaternary ammonium salts. Application : Treatment of any substance P- and neurokinin dependent pathology, in particular analgesia and inflammation.
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