| 摘要 |
A process for preparing an hydroxyketone of the formula (X): <CHEM> wherein Ar represents substituted phenyl, aromatic heterocyclic, or substituted aromatic heterocyclic; R<1> and R<2> independently represents hydrogen, C-1 to C-16 alkyl, aromatic, substituted aromatic, aromatic heterocyclic, substituted aromatic heterocyclic or C-1 to C-5 alkyl covalently bonded to Ar, with the provision that R<1> and R<2> are different. The process comprises contacting a compound of the formula (V): <CHEM> with a solvent, a base and a chiral hydroxylating agent at a temperature of about -85 DEG C or less. Compounds of the formulae <CHEM> also are disclosed. |
