摘要 |
<p>A method for resolving (+)-/α/-(3-benzoylphenyl)propionic acid is disclosed. The method comprises: (i) converting said propionic acid with (-)-cinchonidine in a solvent comprising a mixture of an aliphatic ester and an alkyl alcohol; (ii) separating the diastereomeric salt from such conversion; (iii) purifying said separated diastereomeric salt by a single recrystallization; and (iv) isolating highly pure (+)-α-(3-benzoylphenyl)propionic acid without any further recrystallization.</p> |