发明名称 RESOLUTION OF KETOPROFEN
摘要 <p>A method for resolving (+)-/α/-(3-benzoylphenyl)propionic acid is disclosed. The method comprises: (i) converting said propionic acid with (-)-cinchonidine in a solvent comprising a mixture of an aliphatic ester and an alkyl alcohol; (ii) separating the diastereomeric salt from such conversion; (iii) purifying said separated diastereomeric salt by a single recrystallization; and (iv) isolating highly pure (+)-α-(3-benzoylphenyl)propionic acid without any further recrystallization.</p>
申请公布号 WO1992018455(A1) 申请公布日期 1992.10.29
申请号 US1992002313 申请日期 1992.03.23
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