IMPROVED PROCESS FOR THE PREPARATION OF [1S-(1R*,2S*,3R*)]-N-(4-MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N-[(1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE

摘要

2106673 9218486 PCTABS00016 An improved process for the preparation of ¢1S-(1R*, 2S*, 3R*)!-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-¢(1-_ cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl!-L-alaninamide is described where the key intermediate, 3-(2-amino-4-thiazolyl)-L-alanine is converted without protecting the aminothiazole group to the desired compound, as well as valuable intermediates used in the process.