发明名称 |
BRADYKININ TYPE PEPTIDES |
摘要 |
The substitution of the L-Pro at the 7-position with D-Phe or D-Tic and substitution of the L-Phe at the 8-position with hydroxyproline ethers and thioethers of the peptide hormone bradykinin and other additional substituted analogs of bradykinin converts bradykinin agonists into bradykinin antagonists. The invention further includes additional modifications at other positions within the novel 7- and 8-position modified bradykinin antagonists, which increase enzyme resistance, antagonist potency, and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected as by insect bites. |
申请公布号 |
WO9218155(A1) |
申请公布日期 |
1992.10.29 |
申请号 |
WO1992US03031 |
申请日期 |
1992.04.16 |
申请人 |
NOVA TECHNOLOGY LIMITED PARTNERSHIP |
发明人 |
KYLE, DONALD, JAMES;HINER, ROGER, NEAL |
分类号 |
A61K38/17;A61K38/00;A61P17/00;A61P17/02;A61P25/04;A61P29/00;C07D207/12;C07K7/14;C07K7/18 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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