9-HALOGENE-11BETA-HYDROXI-PROSTAGLANDINE DERIVATIVES METHOD FOR PRODUCING THEM AND THEIR UTILIZATION AS MEDICAMENT

摘要

The invention relates to 9-halogen-11.beta.-hydroxy-prostane derivatives of formula I (I), in which Z means the radicals or , Hal means an .alpha.- or .beta.-position chlorine or fluorine atom, R1 means the radical CH2OH or with R2 meaning a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R1 means the radical with R3 meaning an acid radical or radical R2 and R4 means a cycloalkyl group, and if R2 has the meaning of a hydrogen atom, its salts with physiologically compatible bases and its cyclodextrin clathrates, process for their production and their pharmaceutical use.