| 摘要 |
Benzodiazepines of formula <CHEM> wherein X is N(R,R<1>), OR<4> or SR<5>, R and R<1> are N(R<2>,R<3>) or substituted lower alkyl or an optionally substituted C3-C7-cycloalkyl, aryl, aralkyl or C2-C6-aliphatic hydrocarbon group, this aliphatic group having one or more double or triple bond, or one of R and R<1> is hydrogen, or N(R,R<1>) is an optionally substitued heterocycle with one or more heteroatoms, R<2> and R<3> are H, lower alkyl, aryl or aralkyl, R<4> is lower alkyl or has one of the meanings of R or R<1> with the exception of H and of N(R<2>,R<3>), R<5> is H or lower alkyl or has one of the meanings of R or R<1> with the exception of N(R<2>,R<3>), Y and Z are H, NO2, N(R<2>,R<3>), halogen, CF3, OH, CN or lower alkyl or alkoxy, and A, B and C are H, CH3, C2H5, F or Cl, and pharmaceutically acceptable salts thereof are useful as medicaments especially for the treatment or prophylaxis of viral infections, particularly of retroviral infections, such as HIV 1 and/or HIV 2 infections, or for protecting cells against such infections. |
