发明名称 |
METHOD FOR PRODUCING NEW 2-IMIDAZOLYL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PHARMACEUTICAL PREPARATIVES CONTAINING THEM AS ACTIVE AGENT |
摘要 |
PCT No. PCT/EP91/02228 Sec. 371 Date Jul. 24, 1992 Sec. 102(e) Date Jul. 24, 1992 PCT Filed Nov. 26, 1991 PCT Pub. No. WO89/08646 PCT Pub. Date Sep. 21, 1989.Compounds having formula (I) <IMAGE> (I) wherein Z is -O- or -CH2-; n is 1-6; R is hydrogen, C1-C6 alkyl, phenyl or optionally substituted phenyl-C1-C3 alkyl; R2 is C1-C8-alkyl, aryl-C1-C3 alkyl, C5-C8 cycloalkyl or C5-C8 cycloalkyl-C1-C3 alkyl; each of R3 and R4 independently is hydrogen or C1-C4 alkyl, or taken together with the carbon atom to which they are linked form a C3-C6 cycloalkyl ring; Q is -OR' or -NR'R'' in which R' and R'' are as herein defined, or Q is C1-C8 alkyl, phenyl, phenyl-C1-C3-alkyl, C5-C8 cycloalkyl or C5-C8 cycloalkyl-C1-C3 alkyl, in which both the phenyl and cycloalkyl rings or moieties are optionally substituted as herein defined; and the pharmaceutically acceptable salts thereof; are useful in particular as antidislipidaemic and antiatherosclerotic agents. |
申请公布号 |
HU9202462(D0) |
申请公布日期 |
1992.10.28 |
申请号 |
HU19920002462 |
申请日期 |
1991.11.26 |
申请人 |
FARMITALIA CARLO ERBA S.R.L.,IT |
发明人 |
COZZI,PAOLO,IT;FANCELLI,DANIELE,IT;SEVERINO,DINO,IT;AUGUSTO,CHIARI,IT;GHISELLI,GIANCARLO,IT |
分类号 |
A61K31/415;A61P3/06;A61P9/10;C07D233/54;C07D233/64;C07D405/04 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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