发明名称 |
SAPPHYRINS, DERIVATIVES AND SYNTHESES |
摘要 |
The present invention involves, in addition to many unique substituted sapphyrins, a novel method for synthesizing sapphyrins with good efficiency and high yield. An improved 9-step synthesis of substituted sapphyrins, e.g., the two C2 symmetric sapphyrins, compounds 2 and 4 of FIG. 1C, is described herein. This synthesis involves as an important step the condensation between a tripyrrane diacid and a diformyl bipyrrole. The key tripyrrane component is prepared in three high-yield steps from readily available pyrrolic precursors and the bipyrrole portion is prepared in four steps from ethyl 3-methyl-4-methylpyrrole-2-carboxylate in roughly 33% yield overall.
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申请公布号 |
US5159065(A) |
申请公布日期 |
1992.10.27 |
申请号 |
US19890454298 |
申请日期 |
1989.12.21 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SESSLER, JONATHAN L.;CYR, MICHAEL J. |
分类号 |
A61K41/00;A61K47/48;C07D487/22;C07H15/26;C07H21/00;C12N15/10 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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