Process for the preparation of derivative of 7-[(2-hydroxyimino)-acetamido]-cephalosporanic acid

摘要

A novel process for the preparation of syn isomers of cephalosporanic acid derivatives of the formula <IMAGE> I' comprising reacting first in a solvent and optionally in the presence of a base, a compound of the formula <IMAGE> II with a compound of the formula R4-SO2-Hal III wherein R4 is selected from the group consisting of optionally substituted alkyl, aryl and aralkyl and Hal is a halogen and reacting the resulting product in a solvent and optionally in the presence of a base with a compound of the formula <IMAGE> IV to obtain the compound of formula I' which are known to possess good antibiotic properties.