摘要 |
PURPOSE:To form minute pores of 1mum in the surface of hydroxyapatite used as a separation material for liquid chromatography and provide the separation material having resisting pressure and adaptability effect. CONSTITUTION:Hydroxyapatite in which a mole ratio of Ca to P is 1.67 or more is synthesized by a wet method, it is molded in the form of an arbitrary separation material and baked at 1000 deg.C or higher and surplus CaO is separated and precipitated. The surface of the molding is washed by water, organic solvent and the like, CaO of a surface layer is eluted and minute pores in accordance with the size of the molecule level of the CaO are formed in the surface layer. |