发明名称 |
HERSTELLUNGSVERFAHREN EINES OPTISCH AKTIVEN ALKOHOLS. |
摘要 |
A carbonyl compound represented by the formula: <CHEM> wherein A represents C1-7 alkyl or haloalkyl, optionally substituted phenyl, or optionally substituted benzyl; and B represents C1-4 acyl, C1-7 alkoxycarbonyl, haloalkyl, hydroxycarbonyl, C1-7 alkoxyalkyl, hydroxymethyl, optionally substituted benzoyl or C1-7 alkyl-substituted aminomethyl; or A and B with the adjacent C atom form an optionally substituted cyclic 5- or 6-membered 1,2-diketone, is dissolved in amphiprotic solvent and there is added 100-1/50,000 mol of a ruthenium-optically active phosphine derivative as catalyst, e.g. of formula RuxHyClz(R-BINAP)2-(S)p (III) or [RuH1(R-BINAP)v]Yw (V) wherein BINAP is a specific tertiary phosphine group. The compound (I) is reacted with hydrogen at a pressure of 5-40 kg/cm<2> for 1-48 hours and there is recovered in high yield as product an optically active alcohol of the formula (II) wherein the =C=O group has become =CH-OH. |
申请公布号 |
DE3874619(D1) |
申请公布日期 |
1992.10.22 |
申请号 |
DE19883874619 |
申请日期 |
1988.06.15 |
申请人 |
TAKASAGO INTERNATIONAL CORP., TOKIO/TOKYO, JP |
发明人 |
SAYO, NOBORU, YOKOHAMA-SHI KANAGAWA, JP;KUMOBAYASHI, HIDENORI, KANAGAWA, JP;AKUTAGAWA, SUSUMU, YOKOHAMA-SHI KANAGAWA, JP;NOYORI, RYOJI, NISSHIN-CHOAICHI-GUNAICHI, JP;TAKAYA, HIDEMASA, OKAZAKI-SHI AICHI, JP |
分类号 |
C07D307/33;B01J31/24;C07B31/00;C07B41/02;C07B53/00;C07B61/00;C07C27/00;C07C29/145;C07C31/20;C07C31/36;C07C33/26;C07C35/06;C07C35/08;C07C41/00;C07C41/26;C07C43/13;C07C43/178;C07C51/00;C07C51/367;C07C59/01;C07C59/50;C07C67/00;C07C67/31;C07C213/00;C07C215/08;(IPC1-7):C07C29/136;C07C33/36;C07C35/14 |
主分类号 |
C07D307/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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