PROCESS FOR THE PRODUCTION OF ANTIBIOTICS, DNA-SEQUENCES, RECOMBINANT-DNA-CONSTRUCTS AND MICROBIAL STRAINS USED THEREIN

摘要

The invention concerns a process according to which by means of known microorganisms of the Streptomyces-genus, by transferring into them specific genes from certain microbial strains which produce structurally closely related antibiotics, such antibiotics of the anthracycline group are biotechnically produced, which these microorganisms do not produce naturally. The invention concerns also microorganisms needed in such a process and formed by recombinant-DNA-technology, recombinant-DNA-constructions and DNA-sequences needed therein. The invention belongs to the field of biotechnical production of antibiotics and relates to the application of hybrid antibiotic technology to antibiotics of the anthracycline group.