An intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen.

摘要

The present invention provides an intracorporeally injectable non-toxic composition of atelocollagen having an excellent, long-lasting skin swelling effect due to its low viscosity, good fluidity, easy injectability and low antigenicity (without calcification) properties. The composition is prepared by treating an aqueous suspension of atelocollagen with a buffer for physiological conditions. The suspension can have an atelocollagen content of 55 to 75 mg/ml, where approximately 20 to 100% by weight of the atelocollagen is cross-linked with a polyepoxy compound.