Synthetic polycarboxylates and proteins hydrogels for drug sustained release and process for the production thereof.

摘要

A hydrogel matrix for sustained release of compounds which are endowed with pharmacological activity is disclosed, said matrix preferably being of protein or polypeptide nature and comprising a synthetic polymer having the formula <CHEM> wherein R = (C1-C12)-alkyl, R1 = (C1-C4)-alkyl, R2 = H (m = 1, 3; n = 1-12) or CH3 (m = 1, n = 1-12), a protein component and the compound which is endowed with pharmacological activity. The process for the preparation of said hydrogel matrix is also disclosed. Such matrices are employed for transcutaneous, transdermal and in particular for ophthalmic routes administration, the ophthalmic route being realized through ophthalmic inserts. A particular application of this invention consists of ophthalmic inserts for sustained release of interferon. <IMAGE>