1-(Pyridol[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles, intermediates and a process for their preparation, and their use as medicaments.

摘要

This invention relates to compounds of the formula <CHEM> wherein R1 is hydrogen or loweralkyl; R2 is hydrogen or loweralkyl; and R3 is hydrogen, loweralkyl, halogen, nitro, amino, hydroxy, loweralkoxy, benzyloxy or <CHEM> where R4 is hydrogen or loweralkyl and R5 is loweralkyl, aryl or arylloweralkyl, or R4 and R5 taken together form a heterocyclic ring selected from the group consisting of <CHEM> wherein R6 is hydrogen, loweralkyl, aryl or arylloweralkyl or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful for alleviating depression and various memory dysfunctions characterized by a cholinergic or adrenergic deficit, such as Alzheimer's Disease, and can, therefore, be used as medicaments.