HYDRAZINE CONTAINING CONJUGATES OF POLYPEPTIDES AND GLYCOPOLYPEPTIDES WITH POLYMERS

摘要

Biologically active macromolecular conjugates of a biologically active polypeptide or glycopolypeptide and one or more water-soluble polymer molecules covalently bonded thereto at a reactive carbonyl or carboxylic acid group of a peptide moiety on the polypeptide or glycopolypeptide or at an oxidized carbohydrate moiety of the glycopolypeptide by a linkage containing a hydrazide or hydrazone functional group. The linkage preferably also includes an amino acid or a peptide sequence.