1,2,4-OXADIAZOLE DERIVATIVE HAVING MONOAMINE OXIDASE B ENZYME INHIBITING ACTIVITY AND ITS PRODUCTION

摘要

PURPOSE:To obtain a new compound useful as a treating agent for Parkinson's disease, having excellent MAO-B enzyme inhibiting activity and selective inhibitory action on MAO-B enzyme. CONSTITUTION:A compound shown by formula I (R<1> is lower alkyl, cycloalkyl, etc.; R<2> is lower dialkylamino, cyclic alkylamino, etc.; (n) is 1, 2 or 3) and an acid addition salt such as 3-[4-[3-(1H-imidazoll-yl)propoxy]phenyl]-5-ethyl-1,2,4- oxadiazole. The compound is obtained by reacting an amidoxime derivative shown by formula II with an acyl halide or an acid anhydride in the presence of a base in a solvent.