发明名称 |
Analogs of carbonic anhydrase inhibitors and their use as topical IOP inhibitors |
摘要 |
Analogs are prepared of the carbonic anhydrase inhibitors methazolamide, and dichlorphenamide. The analogs link a cleavable functional group to the pharmacologically active carbonic anhydrase inhibitor resulting in compounds of improved corneal permeability, which are non-irritable to the eye and which are effective topically to inhibit intraocular pressure.
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申请公布号 |
US5157044(A) |
申请公布日期 |
1992.10.20 |
申请号 |
US19900535573 |
申请日期 |
1990.06.11 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
SCHOENWALD, RONALD D.;BARFKNECHT, CHARLES F. |
分类号 |
A61K31/18;A61K31/41;A61K31/433;A61P27/02;A61P43/00;C07C311/16;C07D277/80;C07D285/12;C07D285/125;C07D285/135 |
主分类号 |
A61K31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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