PRODUCTION OF 3-HYDROXYCEPHEM DERIVATIVE

摘要

PURPOSE:To produce a 3-hydroxycephem derivative on an industrial scale at a low cost by reacting a halogenated beta-lactam compound with a metal iodide, etc. CONSTITUTION:The objective compound of formula II is produced by reacting (A) 1mol of a compound of formula I [Ar is (substituted)aryl; R<1> is (protected) amino; R<2> is H or carboxylic acid protecting group; R<3> is H or OH-protecting group; X is halogen) with (B) preferably 0.9-5mol of a metal iodide (e.g. sodium iodide) or an iodide of an ammonium compound (e.g. ammonium iodide) in a solvent (e.g. methanol or acetone) preferably at 0-80 deg.C optionally in the presence of an inorganic reducing agent (e.g. sodium phosphite).