摘要 |
The use of collagen which has been cross-linked by a cross-linking agent to produce collagen threads for forming an implant for filling soft tissue is described. The cross-linking rate is preferably such that there occurs an increase of at least 15 DEG C in the denaturation temperature of the cross-linked collagen relative to the native collagen. It is thereby possible to fill soft tissue, such as wrinkles, with reduced immunogenicity, good filling capacity and extended repair time.
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