1-(PYRIDO[3,4-B]-1,4-OXAZINYL-4-YL)-1H-INDOLES, INTERMEDIATES AND A PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS

摘要

HOE 91/S 009 This invention relates to compounds of the formula <IMG> wherein R1 is hydrogen or loweralkyl; R2 is hydrogen or loweralkyl; and R3 is hydrogen, loweralkyl, halogen, nitro, amino, hydroxy, loweralkoxy, benzyloxy or <IMG> where R4 is hydrogen or loweralkyl and R5 is loweralkyl, aryl or arylloweralky1, or R4 and R5 taken together form a heterocyclic ring selected fom the group consisting of <IMG>, <IMG>, <IMG>, <IMG> <IMG> or <IMG> wherein R6 is hydrogen, loweralkyl, aryl or arylloweralkyl or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful for alleviating depression and various memory dysfunctions characterized by a cholinergic or adrenergic deficit, such as Alzheimer's Disease, and can, therefore, be used as medicaments.