| 摘要 |
<p>A method and system for paracellularly administering pharmacologically-active substances across mammalian epithelial barriers, comprising sequentially administering to predetermined epithelial cells of said mammalian epithelial cell sheets having receptors for tumor necrosis factor located thereon and having a homeostatic tight junctional resistance therebetween, an amount of a biologically-active substance reactive with said receptors for tumor necrosis factor in an amount effective to lower said homeostatic tight junctional resistance to permit paracellular transit of said pharmacologically-active substances across said epithelial cell sheets; and followed by exogenously administering a pharmacologically-active substance in a pharmaceutically-acceptable carrier to said predetermined mammalian epithelial barrier before said tight junctional resistance reverts to said homeostatic state.</p> |
