发明名称 |
METHOD OF IDENTIFYING AND MODULATING THE ACTIVITY OF LABEL RETAINING CELLS FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
摘要 |
Methods of detecting label retaining cells in self-renewing tissues, such as hair follicle, are provided. Methods of modulating the activity of slow-cycling cells and methods of evaluating the efficacy of agents for modulating the activity of stem cell populations are also provided. Generally, cells are continuously labeled, induced into a proliferative phase by exposure to an agent such as TPA or a cytokine, and then observed in relation to established criteria. |
申请公布号 |
WO9217779(A1) |
申请公布日期 |
1992.10.15 |
申请号 |
WO1992US02269 |
申请日期 |
1992.03.20 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;NEW YORK UNIVERSITY |
发明人 |
LAVKER, ROBERT, M.;SUN, TUNG-TIEN;COTSARELIS, GEORGE |
分类号 |
C12Q1/02;C12N5/071;C12N5/074;G01N33/50 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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