| 摘要 |
Compounds of the formula <CHEM> wherein the broken line represents an optional double bond; X is O, S, CH2 or CH2CH2; R<1> is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, C1-C6 alkanoyl, C1-C6 alkyl, and C1-C6 alkyl substituted with 1, 2 or 3 halogen atoms; R<2> is selected from the group consisting of phenyl, substituted phenyl, heterocyclic groups, and substituted heterocyclic groups, said substituted phenyl and substituted heterocyclic groups being substituted with 1 or 2 substituents independently selected from the group consisting of C1-C6 alkyl, trifluoromethyl, and halogen; R<3> and R<4> are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, or trifluoromethyl, or R<3> and R<4>, taken together with the carbon atoms to which they are attached, form a six-membered carbocyclic aromatic ring, said aromatic ring being optionally substituted with one or two substituents selected from the group consisting of halogen, C1-C6 alkyl, and C1-C6 alkyl substituted with 1, 2 or 3 halogen atoms; and the pharmaceutically acceptable salts thereof. The compounds are useful in treating inflammation or other prostaglandin or leukotriene mediated diseases. |
