| 摘要 |
Disclosed is a novel oxazinone derivative represented by formula (I) given below or a pharmaceutically acceptable acid-addition salt thereof, which is useful as an anti-inflammatory agent, an agent for suppressing neutrophil infiltration and as a serine protease inhibitor: . . . ¢I! where A includes, for example, in which W is -O-, -S-, -CH=CH- or -NR9- or means that (CH2)n is directly bonded to (CH2)n, V2 is =CR12- or =N-, and D is 5 to 7-membered carbon ring or hetero ring; X is -O-, -S-, -CO-, or -NR15 or means that A is directly bonded to (CH2)1; Y is -O-, -CH=CH- or -NR16- or means that (CH2)1 is directly bonded to Z; z is -CH2- or -CO-; and 1 is an integer of 0 to 4. Further, R and R1 to R16 are hydrogen atom, lower alkyl group, etc.
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