| 发明名称 |
INTERLEUKIN-8 RECEPTORS AND RELATED MOLECULES AND METHODS |
| 摘要 |
2107682 9218641 PCTABS00017 Disclosed are cDNAs encoding IL-8 receptors and the recombinant proteins expressed from such cDNAs. The recombinant receptor and receptor fragments and analogs are used in methods of screening candidate compounds for their ability to antagonize interaction between IL-8 and an IL-8 receptor; antagonists are used as therapeutics to reduce inflammation. Antibodies specific for IL-8 receptor (or receptor fragment or analog) and their use as a therapeutic are also disclosed.
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| 申请公布号 |
CA2107682(A1) |
申请公布日期 |
1992.10.11 |
| 申请号 |
CA19922107682 |
申请日期 |
1992.04.10 |
| 申请人 |
TRUSTEES OF BOSTON UNIVERSITY (THE);REPLIGEN CORPORATION |
发明人 |
NAVARRO, JAVIER;THOMAS, KATHLEEN M.;WITT, DANIEL P. |
| 分类号 |
A61K39/395;A61K38/00;A61P29/00;C07K14/00;C07K14/52;C07K14/54;C07K14/705;C07K14/715;C07K16/00;C12P21/02;C12R1/91;G01N33/53;(IPC1-7):C12N15/24;C12Q1/02;A61K38/20;C07K16/28;G01N33/52;G01N33/566 |
主分类号 |
A61K39/395 |
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