STABILIZATION AND MAINTENANCE OF THE NERVE GROWTH FACTOR BIOLOGICAL ACTIVITY BY USE OF NATURAL GANGLIOSIDES OR DERIVATIVES THEREOF

摘要

The present invention concerns new, stable and biologically active complex compounds between the proteins and gangliosides, namely, stable and biologically active complexes between the beta subunit of Nerve Growth Factor ( beta NGF) and natural gangliosides or their semisynthetic analogues such as carboxy esters and amides; as well as pharmaceutical compositions containing such complexes, their therapeutic uses and a process for their manufacture.