PRODUCTION OF HIGH-PURITY 1-METHYLPIPERAZINE

摘要

PURPOSE:To produce high-purity 1-methylpiperazine, which is an useful compound whose demand is increasing in recent years as a raw material for medicine and antiparasitic agent at a low cost. CONSTITUTION:Piperazine is subjected to hydrogenation with hydrogen by gradually pressing formaldehyde into piperazine in the presence of hydrogen and hydrogenation catalyst and 1,4-dimethyl-piperazine which is a by-product is removed by azeotropic distillation with water and then rectified to produce high-purity 1-methyl-piperazine.