| 摘要 |
A compound of the formula: wherein R1 is amino or hydroxy; R3 is hydrogen, methyl, or ethyl; and Z is hydroxy, alkoxy, or -NH-C*(COOX)-CH2CH2COOX in which X is hydrogen or alkyl and the configuration about the carbon atom designated * is L. These compounds are useful as intermediates in making pyrido¢2,3-d!pyrimidines of the formula: IA wherein R1 is amino or hydroxy; and R3 is hydrogen, methyl, or ethyl; the configuration about the carbon atom designated being L; (ib) 5,6,7,8-tetrahydropyrido¢2,3-d!-pyrimidines of the formula: IB wherein R1 is amino or hydroxy; and R3 is hydrogen, methyl, or ethyl; the configuration about the carbon atom designated * being L; (ii) the tautomeric forms thereof; and (iii) the pharmaceutically acceptable alkali metal, alkaline earth metal, non-toxic metal, ammonium, and substituted ammonium salts thereof are disclosed. |
