PHENYLALKYL-2,3-DIHYDROBENZOFURANS AND ANALOGS USEFUL AS ANTI-INFLAMMATORY AGENTS

摘要

1760S/0977A 17143 TITLE OF THE INVENTION PHENYLALKYL-2,3-DIHYDROBENZOFURANS AND ANALOGS USEFUL AS ANTI-INFLAMMATORY AGENTS Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduction. These compounds were found to be potent antiinflammatory agents.