| 摘要 |
PURPOSE:To obtain the subject compound having excellent handleability and useful as a raw material for pharmaceuticals, etc., in high yield by reacting a specific 2-substituted-carboxyiodobenzene compound with a specific thiourea compound in the presence of a transition metal complex. CONSTITUTION:The objective compound of formula III and formula IV can be produced by reacting a 2-substituted-carboxyiodobenzene compound of formula I (R is amino, hydroxy, alkylamino, etc.; R<1> is halogen, lower alkyl, nitro or H; the position of the substituent on the benzene ring is arbitrary; n is 1-3) with a thiourea compound of formula II [R<2> and R<3> are (substituted) alkyl, alkylene, cycloalkyl, phenyl, H or amino] in the presence of a transition metal complex such as nickel complex. The molar ratio of the formula II /I is preferably 1.0-1.5. |
