Method and probes for detecting overlaps among large collections of cloned DNA molecules.

摘要

A method and probes for detecting overlaps among cloned DNA molecules includes the steps of hybridizing a labeled low frequency repetitive sequence probe with cloned DNA molecules, at least some of the cloned DNA containing overlaps including low frequency repetitive sequences, and identifying labeled hybridized molecules or fragments of molecules containing the low frequency repetitive sequences as including DNA from the same genomic location.