| 摘要 |
PURPOSE:To obtain the subject compound in high yield at a low cost under mild reaction condition by reacting a specific ketone compound with an oxygen- containing gas in the presence of a nickel compound and an aldehyde compound. CONSTITUTION:The objective compound of formula V is produced by compounding (A) 1mol of a compound of formula I [R<1> and R<2> are aryl substituted with electron-donative group, aliphatic unsatrated hydrocarbon group, group of formula II [R and R<4> are (substituted) alkyl or aryl{ or formula III (R<5> to R<7> are same as R<3> and R<4>); R<1> and R<2> may together form a ring} with (B) 0.1-5mol% of a compound of formula IV [R<8>, R<10>, R<11> and R<12> are lower alkyl, aryl, COOR<14> (R<14> is alkyl or aryl), etc,; R<9> and R<12> are H, halogen, etc., which may have substituent; R<8> and R<9> or R<11> and R<12> may together form a ring] and (C) 1.0-3.0mol of a compound of formula R<17>CHO [R<17> is (substituted) alkyl or aryl] and reacting the compoents in 0.03-5mol% of a solvent such as benzene while supplying the system with a gas containing oxygen at a partial pressure of preferably 1.0-2.0atm. |
